Effient metabolism issues
This is a discussion on Effient metabolism issues within the Managed Care Issues for Oral Drugs forum, part of the Managed Care Drug Coverage category; Anonymous member request: "Does Effient metabolize through the same CYP 2C19 process as Plavix?"...
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03-18-2010, 02:54 PM
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Effient metabolism issues
Anonymous member request:
"Does Effient metabolize through the same CYP 2C19 process as Plavix?" 
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03-19-2010, 01:28 PM
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Re: Effient metabolism issues
It appears that CYP 2C19 is not a major metabolizer of prasugrel. According to Effient prescribing information "[prasugrel] is rapidly hydrolyzed in the intestine to a thiolactone, which is then converted to the active metabolite by a single step, primarily by CYP3A4 and CYP2B6 and to a lesser extent by CYP2C9 and CYP2C19". With regards to drug interactions (other inducers of cytochromes P450 (i.e. CYP2C19) inducers are "not expected to have significant effect on the pharmacokinetics of the active metabolite of prasugrel."
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